Comparison of rat tooth eruption in rats born from diabetic mothers

Background: Tooth eruption begins after crown and root formation may be delayed by gestational diabetes mellitus. Metformin can control blood glucose levels through gluconeogenesis inhibition, consuming thymoquinone for diabetic treatment will regenerate pancreatic β cells reduce oxidative stress. Purpose: The objective of this study is to compare the tooth in rats that were born with are being treated either metformin or thymoquinone. Methods: This used 48 Wistar (Rattus norvegicus L.), rat sample was divided into four groups, including who from healthy mothers, untreated mothers Diabetes induced intraperitoneal injection a single dose streptozotocin (40 mg/kg BB). Each taken simple random sampling different body weight, recorded. Eruptions maxillary right first molar measured cusp alveolar epithelial lining. Results: Based on measurements eruption, it found groups A, C D closer mucosa day 1, 7 14 than group B. statistical analysis, there significant differences (p = 0.03) between B D. Conclusions: Rats have more delays those Thymoquinone has potential an alternative because been shown similarly effective.